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我院从1998年2月～1999年7月用氧氟沙星联合头孢噻肟治疗确诊为耐药伤寒患者64例,随机设计对照组60例单用氧氟沙星进行疗效对比,现总结如下:1 对象与方法1.1 病例选择:124例住院患者经血、骨髓或粪便培养伤寒杆菌阳性并结合临床表现而确诊为伤寒,且经多种抗生素治疗无效者,其中男89例,女35例,年龄15～61岁。随机分为氧氟沙星联合头孢噻肟组(治疗组)和单用氧氟沙星组(对照组)。两组患者在年龄、性别及临床类型等方面比较,差异均无显著性(P>0.05),两组间具有可比性。1.2 治疗方法:(1)治疗组:氧氟沙星每日0.6g,分2次口服;头孢噻肟每日3g,每8小时肌注1g。疗程10天或体温正常后再用药3～5天。共治疗64例;(2)对照组:单用氧氟沙星每日
Our hospital from February 1998 to July 1999 with ofloxacin combined with cefotaxime treatment of patients diagnosed as resistant typhoid 64 cases of randomized design and control group of 60 cases of ofloxacin alone compared the efficacy, are summarized as follows : 1 Subjects and methods 1.1 Case Selection: 124 cases of hospitalized patients with blood, bone marrow or feces culture typhoid bacillus positive and combined with clinical manifestations diagnosed as typhoid fever, and a variety of antibiotics ineffective treatment, including 89 males and 35 females, age 15 ~ 61 years old. Randomly divided into ofloxacin combined with cefotaxime group (treatment group) and ofloxacin group (control group). There was no significant difference between the two groups in terms of age, gender and clinical type (P> 0.05), and comparability was found between the two groups. 1.2 Treatment: (1) treatment group: ofloxacin daily 0.6g, 2 times orally; cefotaxime daily 3g, intramuscular injection of 1g every 8 hours. Medication 10 days or normal body temperature and then medication 3 to 5 days. A total of 64 cases of treatment; (2) control group: ofloxacin alone daily