论文部分内容阅读
金络为α、β受体阻断剂,能明显减轻心肌损害,延缓慢性充血性心力衰竭的进展,降低慢性充血性心力衰竭患者的病死率。金络具有普通β阻滞剂抑制去甲肾上腺素对心肌的毒性作用,降低氧耗同时提供腺嘌呤核苷三磷酸供给,增加心肌肌浆腺嘌呤核苷三磷酸酶活性,使舒张期泵入肌浆网内的腺嘌呤核苷三磷酸及Ca2+增加外,还具有α受体阻滞作用,能降低外周血管阻力,使心排量增加;金络明显改善慢性充血性心力衰竭患者的左心功能,抑制左心室重构,其延缓心衰进程的作用机制与其消除氧自由基、抗氧化、抑制心肌细胞凋亡有关。
Jinluo α, β receptor blockers, can significantly reduce myocardial damage, delay the progress of chronic congestive heart failure, reduce the mortality of patients with chronic congestive heart failure. Jinluo with ordinary β-blockers inhibit norepinephrine on myocardial toxicity, reduce oxygen consumption while providing adenine nucleotide triphosphate supply, increase myocardial sarcoplasmic adenine nucleotide triphosphatase activity, so that diastolic pumping Sarcoplasmic reticulum adenosine triphosphate and Ca2 + increase, but also has the role of α receptor block can reduce peripheral vascular resistance, cardiac output increased; gold network significantly improve the left heart of patients with chronic congestive heart failure Function, inhibit left ventricular remodeling, and its mechanism of delaying the progression of heart failure is related to its elimination of oxygen free radicals, antioxidation and inhibition of cardiomyocyte apoptosis.