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目的比较甘精胰岛素分别联合阿卡波糖及瑞格列奈治疗老年2型糖尿病的疗效。方法9例老年2型糖尿病患者停用原治疗方案,随机分为A组(阿卡波糖组)、B组(瑞格列奈组),两组每天早上皮下注射甘精胰岛素,A组口服阿卡波糖150～300mg/d,B组口服瑞格列奈3～6mg/d,并根据空腹血糖情况调整药物用量,共治疗12周。对比分析两组空腹血糖(FPG)、餐后2h血糖(PPG)和糖化血红蛋白(HbA1c)控制情况及低血糖发生情况。结果治疗后两组FPG、PPG、HbA1c均较治疗前明显下降(P<0.05)。结论甘精胰岛素联合阿卡波糖或瑞格列奈能较好的控制老年2型糖尿病患者血糖及糖化血红蛋白。
Objective To compare the efficacy of insulin glargine combined with acarbose and repaglinide in the treatment of type 2 diabetes in the elderly. Methods Nine elderly patients with type 2 diabetes were discontinued. The patients were randomly divided into group A (acarbose group) and group B (repaglinide group). Both groups were given insulin glargine subcutaneously every morning and group A Acarbose 150 ~ 300mg / d, B group oral repaglinide 3 ~ 6mg / d, and adjust the amount of drug according to fasting blood glucose, a total of 12 weeks of treatment. The fasting blood glucose (FPG), postprandial 2h blood glucose (PPG) and glycosylated hemoglobin (HbA1c) control and hypoglycemia were compared between the two groups. Results After treatment, the FPG, PPG and HbA1c in both groups were significantly lower than those before treatment (P <0.05). Conclusion Glargine combined with acarbose or repaglinide can better control blood sugar and HbA1c in elderly type 2 diabetic patients.