论文部分内容阅读
前言随机对照试验(RCT)中样本含量的重要性日益受到关注。Freiman等人检查了71篇没有检出组间差别的RCT文章的效能(Power),发现有67次试验损失了25％的疗效,甚而有50次损失了50％的疗效。文章的作者们从这些研究中不仅得出了阴性的结论,而且由于样本不足,有可能误入歧途。然而,这并不意味着临床试验中病人越多越好,如果病人的数量超过了实际的需要,将
Introduction The importance of sample content in randomized controlled trials (RCTs) is of increasing concern. Freiman et al. examined the efficacy (Power) of 71 RCT articles that did not detect differences between groups and found that 67 trials lost 25% of the efficacy, and even 50 lost 50%. The authors of the article not only came up with negative conclusions from these studies, but also had the potential to go astray because of insufficient samples. However, this does not mean that the more patients in clinical trials the better, if the number of patients exceeds the actual needs,