Large earthquakes cause observable changes in the Earth’s gravity field, which have been detected by the Gravity Recovery and Climate Experiment (GRACE). Since most previous studies focus on the detection of near-field gravity effects, this study provides the results from the medium- to far-field gravity changes caused by the 2004 Sumatra-Andaman earthquake that are recorded within GRACE monthly solutions. Utilizing a spherical-earth dislocation model we documented that large-scale signals predominate in the global field of the coseismic gravity changes caused by the earthquake. After removing the near-field effects, the coseismic gravity changes show a negative anomaly feature with an average magnitude of -0.18×10-8 m·s-2 in the region ranging ～40° from the epicenter, which is considered as the “medium ffield” in this study. From the GRACE data released by Center for Space Research from August 2002 to December 2008, we retrieved the large-scale gravity changes smoothed with 3 000 km Gaussian ffilter. The results show that the coseismic gravity changes detected by GRACE in the medium field have an average of (-0.20±0.06)×10-8 m·s-2, which agrees with the model prediction. The detection confirms that GRACE is sensitive to large-scale medium-field coseismic gravitational effects of mega earthquakes, and also validates the spherical-earth dislocation model in the medium field from the perspective of satellite gravimetry. Large earthquakes cause observable changes in the Earth’s gravity field, which have been detected by the Gravity Recovery and Climate Experiment (GRACE). Since most previous studies focus on the detection of near-field gravity effects, this study provides the results from the medium- to far-field gravity changes caused by the 2004 Sumatra-Andaman earthquake that were recorded within GRACE monthly solutions. Utilizing a spherical-earth dislocation model we said that large-scale signals predominate in the global field of the coseismic gravity changes caused by the earthquake . After Removing the near-field effects, the coseismic gravity changes show a negative anomaly with an average magnitude of -0.18 × 10 -8 m · s-2 in the region ranging ~ 40 ° from the epicenter, which is considered as the “medium ffield ” in this study. From the GRACE data released by Center for Space Research from August 2002 to December 2008, we retrieved the large-scale gravity changes smoothed with 3 000 km Gaussian ffilter. The results show that the coseismic gravity changes detected by GRACE in the medium field have an average of (-0.20 ± 0.06) × 10-8 m · s-2, which agrees with the model prediction. The detection confirms that GRACE is sensitive to large-scale medium-field coseismic gravitational effects of mega earthquakes, and also validates the spherical-earth dislocation model in the medium field from the perspective of satellite gravimetry.