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Objective:To study therapy with indapamide impairing carbohydrate metabolism in essential hypertension patients and achieve earlier prevention,diagnoses and treatment of diabetes induced by indapamide.Methods:Four cases of essential hypertension patients(1 male and 3 females) were observed through process of therapy with indapamide and laboratory investigations. Results:Afer 4- to 14-month period of therapy with the combination of indapamide (2.5 mg/d) and fosinopril (10 mg/d) in three patients and 6-month period of monotherapy with indapamide (2.5 mg/day) in one patient,glucose levels of all patients increased and achieve criteria of diabetes diagnoses.After 3-to 13-month period of therapy without indapamide,glucose levels of all patients decreased and diabetes disappeared.Conclusion:Therapy with indapamide may induce diabetes in essential hypertension patients.After stopping indapamide,glucose tolerance impairing may be reversed.
Objective: To study therapy with indapamide impairing carbohydrate metabolism in essential hypert patients and achieve ago prevention, diagnoses and treatment of diabetes induced by indapamide. Methods: Four cases of essential hypertensive patients (1 male and 3 females) were observed through process of therapy with indapamide and laboratory investigations. Results: Afer 4- to 14-month period of therapy with the combination of indapamide (2.5 mg / d) and fosinopril (10 mg / d) in three patients and 6-month period of monotherapy with indapamide mg / day) in one patient, glucose levels of all patients increased and achieve criteria of diabetes diagnoses. After 3-to 13-month period of therapy without indapamide, glucose levels of all patients decreased and diabetes disappeared. Confluence: Therapy with indapamide may induce diabetes in essential hypert patients. After stopping indapamide, glucose tolerance impairing may be reversed.