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目的:探讨survivin在成釉细胞瘤中的表达及意义。方法:采用免疫组织化学S-P法检测70例成釉细胞瘤(ameloblastoma,AB)、15例恶性AB、30例正常口腔黏膜中survivin的表达。采用SPLUS13.0软件包对数据进行统计学分析。结果:AB、恶性AB中survivin明显表达,恶性AB中阳性表达率最高,为100%,其次为AB(82.9%);正常口腔黏膜轻微表达,其阳性率为30%,各组间差异显著(P<0.05)。结论:AB中survivin高表达,且明显高于正常口腔黏膜。Survivin可能参与AB的发生与发展,AB的侵袭性增加和恶变与survivin的高表达相关。
Objective: To investigate the expression of survivin in ameloblastoma and its significance. Methods: The expressions of survivin in 70 cases of ameloblastoma (AB), 15 cases of malignant AB and 30 cases of normal oral mucosa were detected by immunohistochemical S-P method. Data were analyzed statistically using SPLUS 13.0 software package. Results: Survivin was significantly expressed in AB and malignant AB, the positive rate was 100% in malignant AB, followed by AB (82.9%). The normal oral mucosa was slightly expressed, with a positive rate of 30% P <0.05). Conclusion: The expression of survivin in AB is higher than that in normal oral mucosa. Survivin may be involved in the occurrence and development of AB, the increased invasiveness and malignant transformation of AB correlate with the high expression of survivin.