检查严重肺炎球菌感染患者45例,年龄14～74岁,男38例,女7例。急性发病,病情迅速恶化:头痛、发烧、畏寒、呕吐,意识丧失。42%的患者血培养肺炎球菌阳性。肺炎并发脑膜脑炎患者血培养阳性率高达75%。肺炎球菌感染的严重性取决于脑的损害(脑膜脑炎)伴深度和长期的昏迷和肺部损害,后者常导致明显的血氧过低,以及发生脑水肿。病情严重20例,极严重16例,死亡9例。极严重病例并发脑膜脑炎和双侧肺炎或脓肿。较轻病例有脑膜炎。血清酶学检查,在急性期第1～3天,37.7%的 45 cases of severe pneumococcal infection were examined, aged 14 to 74 years, 38 males and 7 females. Acute onset, rapid deterioration of the condition: headache, fever, chills, vomiting, loss of consciousness. 42% of patients were positive for pneumococcal cultures. The positive rate of blood culture in patients with pneumonia and meningoencephalitis is as high as 75%. The severity of pneumococcal infection depends on brain damage (meningoencephalitis) with deep and long-term coma and lung damage, which often leads to significant hypoxemia and cerebral edema. 20 cases of serious illness, very serious in 16 cases, 9 cases of death. Very serious cases of meningoencephalitis and bilateral pneumonia or abscess. Lesser cases are meningitis. Serum enzyme tests, in the acute phase of 1 to 3 days, 37.7%