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本文为比较长期采用经皮肤与口服雌激素对血清脂蛋白影响的首篇报道。 受试者为35名健康的绝经前妇女,均因良性病变行全子宫及双附件切除术,术后立即随机分为两组,A组(n=18):口服联结雌激素0.625mg/日;B组(n=17):采用雌激素贴剂0.05mg/日。由于医疗道德问题,未设安慰剂组。实验过程中病人未采用孕激素治疗,未使用影响脂代谢的药物,皆禁吸烟。术前间隔2周两次空腹取血,测定血脂基值,术后3、6、9及12月分别留血复查血脂,包括:总胆固醇、甘油三酯(TG),高密度脂蛋白胆
This article is the first to compare the long-term effects of transdermal and oral estrogen on serum lipoproteins. Subjects were 35 healthy premenopausal women, all due to benign lesions of the hysterectomy and double attachment resection, immediately after the surgery were randomly divided into two groups, A group (n = 18): orally conjugated estrogen 0.625mg / day ; Group B (n = 17): estrogen patch 0.05mg / day. There was no placebo for medical ethics. During the experiment, the patient did not take progestin therapy, did not use drugs that affect lipid metabolism, are banned from smoking. Fasting blood was collected twice a week before operation to determine the level of serum lipids. Blood was collected for blood stasis at 3, 6, 9 and 12 months after operation, including total cholesterol, triglyceride (TG), high density lipoprotein