石英对肺泡巨噬细胞 ( alveolar macrophage,AM)的损伤是矽肺发生发展的关键环节之一。在 AM细胞质膜损伤的研究中 ,对质膜通透性的研究尚少报道 ,而且主要集中在某些特异性通道如钙离子通道的开闭 [1]。关于镧标技术用于检测细胞膜通透性的改变已有报道 ,但通常以整块组织进行 Quartz damage of alveolar macrophages (AM) is one of the key steps in the development of silicosis. In the study of plasma membrane damage in AM cells, the research of plasma membrane permeability is seldom reported, and it is mainly focused on the opening and closing of some specific channels such as calcium channels [1]. Lanthanum standard techniques for the detection of cell membrane permeability changes have been reported, but usually carried out as a whole piece of tissue