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Restenosis rate after coronary angioplasty has been up to 30%-40%. To solve this problem, we studied the effects of Andrographis Paniculata Nees (APN) and fish oil (FO, ω3 polyunsaturated fatty acids over 70%) on atheroselerotic stenosis and restenosis after experimental angioplasty and the relevant mechanisms of APN and FO. Preliminary results showed that APN can significantly alleviate atherosclerotic iliac artery stenosis induced by both decndothelialization and high cholesterol diet (HCD) and restenosis following angioplasty in rabbits. FO showed the same but milder effects than APN did. Both APN and FO significantly inhibited blood monocytes to secrete growth factors in vivo. Ca~(++) -ATPase activity of cell membrane of atherosclerotic rabbits was significantly decreased, while APN or FO, especially the former alleviated this reduction. Refined extract of APN significantly decreased in vitro resting platelet [Ca~(++)]_i and in vivo the resting and thrombin-stimulated platelet [Ca~(++)]_i after oral
Resolve rate of coronary angioplasty has been up to 30% -40%. To solve this problem, we studied the effects of Andrographis Paniculata Nees (APN) and fish oil (FO, ω3 polyunsaturated fatty acids over 70%) on atheroselerotic stenosis and restenosis after experimental angioplasty and the relevant mechanisms of APN and FO. Preliminary results showed that APN can significantly alleviate atherosclerotic iliac artery stenosis induced by both deciduation and high cholesterol diet (HCD) and restenosis following angioplasty in rabbits. FO showed the same but milder effects than APN did. Both APN and FO significantly inhibited blood monocytes to secrete growth factors in vivo. Ca ~ (++) -ATPase activity of cell membrane of atherosclerotic rabbits was significantly decreased while APN or FO, especially the former alleviated this reduction. extract of APN significantly decreased in vitro resting platelet [Ca ~ (++)] _ i and in vivo the resting and thrombin-stimulated platelet [Ca ~ (++)] _ i after oral