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目的:探讨氯氮平的使用剂量与癫痫发作的影响关系。方法:回顾性调查1988年1月至1995年12月使用氯氮平治疗的1303例住院病例,采用自制《氯氮平临床使用调查表》逐一登记,所得数据处理由微机完成。结果:氯氮平引起癫痫发作总的发生率为11.5％,若将日剂量大小分高、中、低三组,其发生率依次为25.97％、6.46％、9.05％。其中高剂量的单用药和多药联用的发生平差别极显著(X~2=7.1405,P<0.01),而低、中剂量二组之间则无统计学上的差异。结论:氯氮平所致的癫痫发作可能与用药剂量、多药联用、调整药量过快等因素有关。
Objective: To investigate the relationship between the dosage of clozapine and the seizure. Methods: A retrospective survey of 1303 hospitalized cases treated with clozapine from January 1988 to December 1995 was conducted one by one using a homemade questionnaire of clinical use of clozapine, and the data processing was completed by a microcomputer. Results: The overall incidence of seizures caused by clozapine was 11.5%. If the daily dose was divided into high, medium and low groups, the incidence rates were 25.97%, 6.46% and 9.05% respectively. There was no significant difference between high-dose single-agent and multi-drug combinations (X ~ 2 = 7.1405, P <0.01), but there was no significant difference between the two groups. Conclusion: Epileptic seizures caused by clozapine may be related to dosage, combination of multiple drugs and excessive dosage adjustment.