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目的探讨血清抗C1q抗体(C1qAb)与系统性红斑狼疮(SLE)疾病活动、狼疮肾炎(LN)的关系。方法应用酶联免疫吸附试验(ELISA)检测60例SLE患者(A组),40例非SLE的自身免疫性疾病患者(B组),40例非LN肾脏疾病患者(C组),30例健康对照者(D组)的血清C1qAb水平。结果①A组患者血清C1qAb水平显著高于C组患者(P<0.05),C组患者血清C1qAb水平显著高于B组(P<0.05),B组患者血清C1qAb水平显著高于D组(P<0.05)。②活动期SLE患者血清C1qAb水平显著高于稳定期SLE患者(P<0.05)。③LN患者血清C1qAb水平显著高于非LN的SLE患者(P<0.05)。结论血清C1qAb水平可作为判断SLE患者病情活动情况、并发LN与否的重要指标。
Objective To investigate the relationship between serum anti-C1q antibody (C1qAb) and systemic lupus erythematosus (SLE) disease activity and lupus nephritis (LN). Methods Sixty patients with SLE (group A), 40 patients with non-SLE autoimmune diseases (group B), 40 patients with non-LN renal disease (group C) and 30 healthy people were enrolled in the study. The level of serum C1qAb in control subjects (Group D). Results ① The level of serum C1qAb in group A was significantly higher than that in group C (P <0.05). The level of C1qAb in group C was significantly higher than that in group B (P <0.05), while the level of C1qAb in group B was significantly higher than that in group D (P < 0.05). ② The level of serum C1qAb in patients with active SLE was significantly higher than that in patients with stable SLE (P <0.05). ③ The level of serum C1qAb in LN patients was significantly higher than that in non-LN patients (P <0.05). Conclusion The level of serum C1qAb can be used as an important index for judging the condition of patients with SLE and complicated with LN.