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胃的生理学及病理学知识的进展为外科治疗消化性溃疡提供了理论基础,对不同原因引起的溃疡采用不同的手术方法,这对于预防复发和减少木后并发症具有重要意义。在溃疡的病因中传统学说很多,但归纳起来概为两类,即侵袭因子和防御因子之间的动态平衡失调。侵袭因子胃的侵袭因子主要为胃酸和胃蛋白酶。胃酸由壁细胞分泌,现已知壁细胞表面有三种受体,即乙酰胆碱受体、胃泌素受体和组织胺H_2受体,迷走神经兴奋时释放的乙酰胆碱(Ach),胃窦部G细胞受刺激时释放的胃泌素(gastrin),胃壁中肥大细胞受刺激释放的组织胺H_2受体均可刺激壁细胞产生胃酸。至于胃酸分泌量的多少则有赖于如下
Advances in the physiology and pathology of the stomach provide a theoretical basis for the surgical treatment of peptic ulcer disease and the use of different surgical procedures for ulcers caused by different causes, which is of great importance for the prevention of recurrence and the reduction of complications after wood. There are many traditional theories in the etiology of ulcers, but they are summed up in two categories, that is, the imbalance of dynamic balance between the invasion factor and the defense factor. Invasive factors The gastric invasion factors are mainly gastric acid and pepsin. Gastric acid is secreted by parietal cells. It is known that there are three receptors on the surface of parietal cells: acetylcholine receptor, gastrin receptor and histamine H_2 receptor, acetylcholine (Ach) released during excitement of vagus nerve and G cells in gastric antrum Gastrin released during stimulation, histamine H 2 receptors released by stimulated mast cells in the stomach wall stimulate the parietal cells to produce stomach acid. The amount of gastric acid secretion depends on the following