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目的探讨多发性骨髓瘤(MM)继发急性淋巴细胞性白血病(ALL)1例的病因、临床表现、临床分型、分期、诊断、治疗方法等并文献复习。方法临床诊断1例MM继发ALL,分析患者临床资料,并就相关文献进行复习。结果该患者确诊MM 7年后继发急性B前体淋巴细胞性白血病,经ICOVLP等方案化疗后达完全缓解。结论 MM继发ALL为罕见病例,其机制可能与烷化剂的使用及免疫缺陷有关。
Objective To investigate the etiology, clinical manifestation, clinical classification, staging, diagnosis and treatment of 1 case of multiple myeloma (MM) secondary acute lymphoblastic leukemia (ALL) and to review the literature. Methods Clinical diagnosis of 1 case of MM secondary ALL, clinical data analysis, and review of the relevant literature. Results The patient was diagnosed with MM secondary to acute B-precursor lymphoblastic leukemia after 7 years of treatment. The complete remission was achieved after chemotherapy with ICOVLP. Conclusion MM is a rare case of secondary ALL, the mechanism may be related to the use of alkylating agents and immunodeficiency.