It is unclear whether the model for end-stage liver disease excluding international normalized ratio(MELD-Ⅺ),in addition to the Thrombolysis In Myocardial Infarction(TIMI)risk score,had prognostic val-ue in patients with ST-segment elevation myocardial infarction(STEMI)undergoing percutaneous coronary inter-vention(PCI).Methods 189 STEMI patients undergoing PCI were consecutively included and classified into two groups based on the cut-off of MELD-Ⅺ,which was determined by receiver operating characteristic(ROC)curve analysis:low MELD-Ⅺ group(＜10,n=135)and high MELD-Ⅺ group(≥10,n=54).The association of MELD-Ⅺ with adverse events was analyzed.Results During hospitalization,5(2.6％)patients died,57(30.2％)suffered acute heart failure,4(2.1％)needed renal replacement treatment,2(1.1％)suffered stroke and 1(0.5％)received target vessel revascularization.ROC curve analysis showed that MELD-XI≥10 was an optimal cut-off for predicting in-hospital MACEs[area under the curve(AUC):0.684,95％CI:0.599-769,P＜0.001].The in-hospital major adverse clinical events(MACEs)was significantly higher in patients with high MELD-XI(51.9％vs.23.0％,P＜0.001).Multivariate analysis showed that MELD-Ⅺ≥10 was an independent risk factor for in-hospital MACEs after adjusting for TIMI risk score(OR:3.59,95％CI:1.79-7.19,P＜0.001).Conclusions MELD-XI,in addition to the TIMI risk score,might provide prognostic value for STEMI patients undergoing PCI.