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餐后高血糖表现为餐后血糖的高峰,这可以引起内皮细胞功能障碍、炎症反应和氧化应激,进而导致动脉粥样硬化的进展和心血管事件的发生。已有资料显示餐后高血糖甚至糖耐量减低即可使动脉粥样硬化和心血管事件更易于发生。有证据显示餐后高血糖可独立预测心血管事件的发生,而空腹高血糖则不能。我们提出“血管衰竭(vascular failure)”的概念,用以概括血管功能障碍的所有表现,包括从危险因素到动脉粥样硬化性疾病晚期。因此餐后高血糖是造成血管衰竭的一种非常重要的病理生理状态。因此,控制餐后高血糖应该作为预防血管衰竭一个潜在的目标而成为未来临床研究的焦点。
Postprandial hyperglycemia is manifested as the peak of postprandial blood glucose, which can cause endothelial dysfunction, inflammation and oxidative stress, leading to the development of atherosclerosis and cardiovascular events. It has been reported that postprandial hyperglycemia and even impaired glucose tolerance can make atherosclerosis and cardiovascular events more prone to occur. There is evidence that postprandial hyperglycemia independently predicts cardiovascular events, whereas fasting hyperglycemia does not. We propose the concept of “vascular failure” to summarize all manifestations of vascular dysfunction, including from risk factors to advanced stages of atherosclerotic disease. Therefore, postprandial hyperglycemia is a very important pathophysiological condition that causes vascular failure. Therefore, controlling postprandial hyperglycemia should be the focus of future clinical research as a potential target for preventing vascular failure.