椎间失稳诱发椎间盘退变的超微结构改变

来源 :中国临床解剖学杂志 | 被引量 : 0次 | 上传用户:ewt43grfdger
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目的:观察新西兰大白兔腰椎关节突关节破坏致椎间盘退变的超微结构变化。方法:24只新西兰大白兔,随机分组骨性手术组(16只)和软组织手术组(8只)。骨性手术组完整切除L4、L5双侧下关节突,L4-5、L5-6为实验组椎间盘,L3-4、L6-7为自身对照组椎间盘。软组织手术组仅剥离L3至L7的椎旁肌肉,L4-5、L5-6为实验对照组椎间盘。术后1、2、4及8月行电子显微镜检查。结果:术后4月,各组椎间盘开始出现退变细胞,表现为外形不规则,细胞膜破裂,线粒体肿胀,核浓缩,核膜皱缩,异染色质较正常增加,核仁消失。
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