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目的探讨慢性阻塞性肺疾病(简称慢阻肺)患者血浆血栓素B2(TXB2)和6-Keto-PGF1a水平与慢阻肺合并肺动脉高压的关系。方法检测72例慢阻肺患者TXB2和6-Keto-PGF1a水平,所有研究对象均应用心脏超声测定肺动脉压,按是否存在肺动脉高压再将72例患者分为单纯慢阻肺组和慢阻肺合并肺动脉高压组,比较两组研究对象的血浆中TXB2和6-Keto-PGF1a水平,同时将TXB2与肺动脉压进行相关分析。结果 72例慢阻肺患者有32例存在肺动脉高压。慢阻肺合并肺动脉高压组TXB2和6-Keto-PGF1a水平明显高于单纯慢阻肺组(P<0.05)。慢阻肺合并肺动脉高压组肺动脉压与TXB2水平呈正相关(r=0.475,P<0.05)。结论血浆TXB2和6-KetoPGF1a可能参与慢阻肺并肺动脉高压形成,而TXB2一定程度上可反映肺动脉压水平。
Objective To investigate the relationship between the levels of TXB2 and 6-Keto-PGF1a in patients with chronic obstructive pulmonary disease (COPD) and chronic obstructive pulmonary disease (pulmonary hypertension). Methods The levels of TXB2 and 6-Keto-PGF1a in 72 COPD patients were detected. All subjects were asked to measure pulmonary arterial pressure by echocardiography. According to the existence of pulmonary hypertension, 72 patients were divided into simple COPD group and COPD group In the pulmonary hypertension group, the levels of TXB2 and 6-Keto-PGF1a in the two groups were compared, and the correlation between TXB2 and pulmonary arterial pressure was also analyzed. Results Thirty-two patients with COPD had pulmonary hypertension. The levels of TXB2 and 6-Keto-PGF1a in chronic obstructive pulmonary disease group were significantly higher than those in chronic obstructive pulmonary disease group (P <0.05). Pulmonary arterial pressure in chronic obstructive pulmonary disease group with pulmonary hypertension was positively correlated with TXB2 level (r = 0.475, P <0.05). Conclusions Plasma TXB2 and 6-KetoPGF1a may be involved in COPD and pulmonary hypertension, while TXB2 may reflect pulmonary arterial pressure to some extent.