论文部分内容阅读
目的:探讨石杉碱甲胃膨胀片的释药机制及影响因素。方法:以PEO为骨架材料,PVA为助膨剂,MCC为填充剂,运用Ritger-Peppas方程释放指数n值,评价PEO,PVA,MCC等对释药速率的影响。结果:胃膨胀片的释药速率随PEO,PVA含量增高而变快,而MCC对释药速率没有明显影响。经处方筛选优化后制备的膨胀片,药物释放曲线符合Higuchi方程,释药机制是扩散和凝胶骨架溶蚀2种机制的协同作用结果的非Fick扩散。结论:PEO,PVA均可影响法石杉碱甲胃膨胀片中主药的释放,而MCC影响不明显。药物释药机制用Ritger-Peppas方程进行描述后,结论是释药机制符合非Fick扩散。
Objective: To investigate the drug release mechanism and influencing factors of Huperzine A gastric augmented tablets. Methods: PEO was used as skeleton material, PVA as swelling aid and MCC as filler. Ritger-Peppas equation was used to release the index value n, and the effects of PEO, PVA, MCC on drug release rate were evaluated. Results: The rate of drug release from gastric expansive tablets increased with the increase of PEO and PVA content, while MCC had no significant effect on drug release rate. After the optimized preparation of the expanded tablets, the drug release curve was in line with the Higuchi equation, and the drug release mechanism was a non-Fick diffusion resulting from the synergistic effect of diffusion and gel skeleton erosion. Conclusion: Both PEO and PVA can affect the release of the main drug from huperzine A gastric augmented tablets, but the effect of MCC is not obvious. After the drug release mechanism was described using the Ritger-Peppas equation, the conclusion was that the drug release mechanism was consistent with non-Fick diffusion.