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近年来,越来越多的抗体被用于疾病的诊断与治疗,已占据生物药品市场的20%,对抗体的大量需求就要求我们对新的抗体纯化策略进行探索。在过去的几十年里,学术界和产业上的进步共同推动了抗体分离纯化技术的发展,色谱法已经成为抗体分离纯化的一个重要方法,并将继续在抗体纯化领域发挥重要作用。文章对当前的色谱法纯化抗体的技术及其应用进行了一个简要的综述。
In recent years, more and more antibodies are being used in the diagnosis and treatment of diseases, accounting for 20% of the biopharmaceutical market. The huge demand for antibodies requires us to explore new antibody purification strategies. Over the past few decades, advances in academia and industry have led to the development of antibody purification technologies. Chromatography has become an important method for the isolation and purification of antibodies and will continue to play an important role in the field of antibody purification. The article gives a brief overview of current chromatography-based antibody purification technologies and their applications.