较系统地探索了用氯甲酸酯类化合物脱Ｎ甲基的反应条件及中间体氨基甲酸酯的水解条件，以Ｌｅｗｉｓ及软硬酸碱理论为指导成功地改进了三溴化硼脱Ｏ甲基方法，提出以氯甲酸α氯乙酯代替溴化氰以及改进的三溴化硼法作为新药纳曲酮合成中相应的方法 The reaction conditions of removing Nmethyl groups with chloroformates and the hydrolysis conditions of intermediate carbamates were systematically explored. Taking Lewis and the theory of hard and soft acids and bases as the guide, the deboronation of boron tribromide was successfully improved  methyl method, proposed chlorocarbonate  α  chloroethyl bromide instead of cyanogen bromide and improved boron tribromide as a new drug naltrexone synthesis in the corresponding method