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粘附分子在疟原虫子孢子(sporozoites)粘附入侵过程中起重要作用。子孢子表面的粘附分子CSP、SSP2/TRAP与肝细胞表面的粘附分子HSPGS能特异结合,结合部位在CSP、SSP2/TRAP的Region Ⅱ-plus区与HSPGS的GAAG区。保持Region Ⅲ-plus与GAG分子结构的完整性是子孢子入侵肝细胞的分子基础。研制阻止子孢子粘附肝细胞的粘附抑制剂,在疟疾预防上具有重要意义。
Adhesion molecules play an important role in the invasion of the sporozoites. The adhesion molecules CSP and SSP2 / TRAP on the surface of sporozoites could specifically bind to HSPGS on the surface of hepatocytes. The binding sites were in the region Ⅱ-plus of CSP, SSP2 / TRAP and GAAG of HSPGS. Maintaining the integrity of the molecular structure of Region III-plus and GAG is the molecular basis of sporozoite invasion of hepatocytes. The development of adhesion inhibitors that prevent the attachment of sporozoites to hepatocytes is of great importance in the prevention of malaria.