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目的 探讨康复训练对脑梗死大鼠学习记忆与健侧海马神经元NMDA受体通道动力学特性的影响。方法 将大鼠随机分为模型组、康复组及正常组 ,分别经过康复训练后 ,采用细胞贴附式记录海马神经元NMDA受体的单通道电流。结果 康复训练组大鼠海马神经元NMDA受体以 35pS通道短开放为主 ,2 0pS短开放和长开放通道以及 35pS短开放时间和概率与正常组比较无显著意义 ,无正常组出现的 35pS长通道 ;模型组以 2 0 pS通道开放为主 ,2 0pS短开放和长开放两个时间常数明显短于康复组同类通道 ,35pS通道短开放时间常数和开放概率也低于康复组 ,无 35pS长开放通道。结论 康复训练促进脑梗死大鼠学习记忆能力的恢复是通过健侧海马神经元NMDA受体通道特性的改变而实现的
Objective To investigate the effects of rehabilitation training on learning and memory and the dynamic characteristics of NMDA receptor channels in contralateral hippocampal neurons of cerebral infarction rats. Methods The rats were randomly divided into model group, rehabilitation group and normal group. After rehabilitation training, the single channel currents of NMDA receptor in hippocampal neurons were recorded by cell attachment method. Results The NMDA receptor in hippocampal neurons of rats in rehabilitation training group was mainly open in the 35pS channel. There was no significant difference in the short open time and open channel length of 20pS and the short open time of 35pS compared with the normal group. The 35pS length The model group was mainly open with 20 pS channels. The time constants of short opening and long opening of 20pS were significantly shorter than that of the same channel in the rehabilitation group, and the short opening time and opening probability of the 35pS channel were also lower than those of the rehabilitation group Open access. Conclusion Rehabilitative training can promote the learning and memory of rats with cerebral infarction through the alteration of NMDA receptor channels in the contralateral hippocampal neurons.