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目的:探究BMP-7在子痫前期肾脏损伤中的表达及临床意义。方法:选取2012年3月到2013年12月我院妇产科收治的98例子痫前期肾脏损伤患者作为研究对象,以30例健康孕妇为对照,分别采用ELISA方法检测血液、尿液中BMP-7蛋白、尿β2微球蛋白(β2-MG)浓度,以苄索氯胺比浊法测定24 h尿蛋白定量。结果:1与对照组相比,子痫前期肾脏损伤患者尿液及血清BMP-7蛋白浓度显著降低(P<0.05);2随着病程进展,子痫前期组尿液血清BMP-7蛋白浓度、尿白蛋白定量、β2-MG显著升高(P<0.05);3子痫前期组尿液、血清BMP-7蛋白浓度分别与尿白蛋白定量、β2-MG成正相关(P<0.05)。结论:子痫前期肾脏损伤患者血清BMP-7蛋白水平显著降低,可用于评估子痫前期肾脏损伤进展,对临床具有指导意义。
Objective: To investigate the expression and clinical significance of BMP-7 in preeclampsia kidney injury. Methods: From March 2012 to December 2013, 98 cases of preeclampsia kidney injury admitted to our department were selected as research objects. 30 healthy pregnant women were selected as control. The levels of BMP- 7 protein and urinary β2-microglobulin (β2-MG) concentrations were determined 24 h urinary protein by benzodiazepine nephelometry. Results: 1 Compared with the control group, the urine and serum BMP-7 protein in preeclampsia patients with kidney injury significantly decreased (P <0.05) .2 As the course of disease progressed, the serum levels of BMP-7 in preeclampsia , Urinary albumin and β2-MG were significantly increased (P <0.05) .3 The levels of urinary and serum BMP-7 in preeclampsia group were positively correlated with urinary albumin and β2-MG respectively (P <0.05). Conclusion: The serum level of BMP-7 protein in preeclampsia patients with kidney injury is significantly lower, which can be used to evaluate the progress of renal injury in preeclampsia and has clinical significance.