延胡索是一种常用中药,它可分离得到一些重要成份——脱氢紫堇碱(DHC)与四氢巴马丁(THP)等。它们的结构有相似性,但药理功能不同。DHC是治疗冠心病的有效成份,THP则有较强的镇静作用,天然延胡索DHC含量较低,由半合成法制得的DHC其理化性质、药理与毒性实验均与天然DHC相似。DHC与THP(图1)的晶体结构已有测定。我们在此基础上 Corydalis is a commonly used traditional Chinese medicine, it can be isolated from some of the important ingredients - dehydration corydalis (DHC) and tetrahydropalmatine (THP) and so on. Their structure is similar, but pharmacological functions are different. DHC is an active ingredient in the treatment of coronary heart disease, THP has a strong sedative effect, natural DHT DHC content is low, semi-synthetic DHC prepared by its physical and chemical properties, pharmacology and toxicity experiments are similar to the natural DHC. The crystal structures of DHC and THP (Figure 1) have been determined. We are on this basis