隐球菌性脑膜炎有亚急性、慢性脑膜炎的特征,在艾滋病患者中发生率为5～8%,但是更加致命的是机会感染。现在二性霉素B的静脉注射(0.5～1mg/kg/日)已显示明显的杀菌作用,常作为首选用药,但其副作用明显,使用后常发生发热、恶心、呕灶、静脉炎。用药中有一定肾损伤等发生,也不易透过血脑屏障。现通常采用与二氟康并用,减少二性霉素B的用量,以减轻其副作用的给药方法。 Cryptococcal meningitis is characterized by subacute and chronic meningitis, occurring in 5-8% of AIDS patients, but is more fatal as an opportunistic infection. Now amphotericin B intravenous injection (0.5 ~ 1mg / kg / day) has shown significant bactericidal effect, often as the preferred drug, but its obvious side effects, often occur after the use of fever, nausea, vomiting, phlebitis. Medication in a certain kidney damage occurs, it is not easy to penetrate the blood-brain barrier. Is usually used in combination with difluoride, reduce the amount of amphotericin B, to reduce the side effects of its administration.