论文部分内容阅读
目的了解血清Ⅵ型胶原在评估日本血吸虫病肝纤维化的程度及疗效中的作用。方法对感染日本血吸虫的小鼠和５９例经秋水仙碱或安慰剂治疗的晚期血吸虫病患者血清Ⅵ型胶原水平进行动态观察，同时对小鼠肝脏病理改变及患者肝脏Ｂ超和各临床指标作了观测。结果小鼠血清Ⅵ型胶原水平在感染后进行性升高，并与肝脏病理变化基本一致；患者血清Ⅵ型胶原较正常人也有明显升高（Ｐ＜０．０１），但治疗组在治疗结束后有所下降，而对照组则显著升高，差异有显著性（Ｐ＜０．０１）。结论血清Ⅵ型胶原可能是监测血吸虫病肝纤维化进展及药物疗效的敏感指标。
Objective To understand the role of serum type Ⅵ collagen in the assessment of the degree and efficacy of hepatic fibrosis in schistosomiasis japonica. Methods The levels of serum type Ⅵ collagen in mice infected with Schistosoma japonicum and 59 cases of advanced schistosomiasis treated with colchicine or placebo were observed. The pathological changes of liver and the clinical indexes of liver in patients with liver biopsy Observed. Results The level of collagen type Ⅵ in mice serum increased progressively after infection and was consistent with the pathological changes of liver. The serum level of type Ⅵ collagen was also significantly increased (P <0.01) in patients, but the treatment group was at the end of treatment After the decline, while the control group was significantly higher, the difference was significant (P <0.01). Conclusion Serum type Ⅵ collagen may be a sensitive indicator to monitor the progress of liver fibrosis and drug efficacy in schistosomiasis.