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20种二唑硫醚 (3a～ 3j)及砜 (4a～ 4 j)衍生物通过二唑巯醇 (2a～ 2j)与二唑氯甲烷 (1)缩合及氧化被合成 ,结构由IR、1HNMR、MS和元素分析确证。体外抗活性结果表明 ,在质量分数 0 0 1%的浓度下 ,硫醚衍生物 3b对金黄色葡萄球菌、3h对变形杆菌表现较强的抑制活性 ,而砜衍生物 4b、4c、4d和 4f对大肠杆菌表现较强的抑制活性 ,其余化合物的抑菌活性皆不明显
20 kinds of oxadiazole thioethers (3a ~ 3j) and sulfone (4a ~ 4j) derivatives were synthesized by the condensation and oxidation of azulethiazole thiol (2a ~ 2j) IR, 1HNMR, MS and elemental analysis confirmed. The results of in vitro antibacterial activity showed that the thioether derivative 3b showed strong inhibitory activity against Proteus spp. For Staphylococcus aureus at the concentration of 0.01%, while the sulfone derivatives 4b, 4c, 4d and 4f Escherichia coli showed strong inhibitory activity, the rest of the compounds antibacterial activity are not obvious