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本研究对８例健康男性志愿受试者，进行了拉氧头孢粉针剂ｉｖ与ｉｍ两种给药方式的药代动力学研究。给药剂量均为１０００ｍｇ，测定方法为微生物测定法和高压液相测定法平行进行，数据用３Ｐ８７计算机程序处理。结果显示，血药浓度数据符合二室开放模型，两种测定方法所得结果相似，ｉｖ最高浓度分别为１２２．９ｍｇ／１和１５０．１ｍｇ／ｌ。Ｔ_（１／２）β分别为２．９４和２．５４ｈ。Ｃｌｓ分别为２．３９和３．２６ｍｌ／ｍｉｎ。ＡＵＣ分别为４３０．７和３２２．８ｍｇ·ｌ~（－１）·ｈ~（－１）。Ｖ分别为８．６２和８．９６１。ｉｍ峰浓度分别为５４．１和５６．８ｍｇ／ｌ，达峰时间分别为１．１１和１．４９ｈ。Ｔ_（１／２）β分别为３．３７和２．７４ｈ。Ｔ_（１／２）Ｋａ分别为０．４７和０．５６ｈ。Ｃｌｓ分别为２．３４和３．７５ｍｌ／ｍｉｎ。ＡＵＣ分别为３２９．０和３０９．７ｍｇ·ｌ~（－１）·ｈ~（－１）。Ｖ分别为１２．７和１０．２１。结果表明两种测定方法所得结果没有明显差异。
In this study, 8 healthy male volunteers were subjected to oral administration of oral administration of oral administration of oral administration of both oral administration of iv and im two modes of pharmacokinetics. The dosage was 1000mg, the determination method for the determination of microorganisms and high-pressure liquid phase parallel method, the data using 3P87 computer program. The results showed that the blood concentration data in line with the two-compartment open model, the results obtained by the two methods were similar, the highest iv concentrations were 122.9mg / 1 and 150.1mg / l. T_ (1/2) β were 2.94 and 2.54 h respectively. Cls were 2.39 and 3.26 ml / min, respectively. AUC were 430.7 and 322.8 mg · l -1 · h -1, respectively. V are 8.62 and 8.961 respectively. The peak concentrations of im were 54.1 and 56.8 mg / l, respectively. The peak time was 1.11 and 1.49 h, respectively. T_ (1/2) β were 3.37 and 2.74h, respectively. T_ (1/2) Ka were 0.47 and 0.56h respectively. Cls were 2.34 and 3.75 ml / min, respectively. AUC were 329.0 and 309.7 mg · l -1 · h -1, respectively. V are 12.7 and 10.21 respectively. The results show that there is no significant difference between the two methods.