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[Objective] This study aimed to analyze the deprotection of acetyl group on amino group.[Method] A simple,convenient one-pot amino protection group of amide removed by thionyl chloride and pyridine via efficient chlorination and hydrolysis with 1,2-dichloroethane as solvent at ambient temperature has been developed.[Result] Pyridine is crucial to the reaction;the best solvent is 1,2-dichloroethane,and the most suitable reaction temperature is the ambient temperature;in addition,the yield is the highest as the molar ratio of pyridine to N-(4-bromophenyl) acetamide is 1:1.[Conclusion] The significant features of this protocol include short reaction time,cleaner reaction profiles,under mild reaction conditions and easy purification,and simple workup that precludes the use of toxic solvents.
[Objective] This study aimed to analyze the deprotection of acetyl group on amino group. [Method] A simple, convenient one-pot amino protection group of amide removed by thionyl chloride and pyridine via efficient chlorination and hydrolysis with 1,2-dichloroethane as solvent at ambient temperature has been developed. [Result] Pyridine is crucial to the reaction; the best solvent is 1,2-dichloroethane, and the most suitable reaction temperature is ambient temperature; in addition, the yield is the highest as the molar ratio of pyridine to N- (4-bromophenyl) acetamide is 1: 1. [Conclusion] The significant features of this protocol include short reaction time, cleaner reaction profiles, under mild reaction conditions and easy purification, and simple workup that precludes the use of toxic solvents.