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rn目的探讨肾母细胞瘤过度表达基因CCN3在宫颈癌的表达及临床意义。方法应用RT-PCR技术检测25例宫颈癌组织及癌旁正常组织CCN3mRNA表达水平,免疫组化法检测43例宫颈癌组织及正常宫颈组织CCN3表达,分析其表达与临床病理特征的关系。结果宫颈癌组织CCN3mRNA表达水平明显高于正常宫颈组织(P“,”Objective To investigate the expression and clinical significance of CCN3 gene in cervrcal cancer.Methods The expressions of CCN3 mRNA in cervical cancer and tumor-adjacent normal tissues of 25 cases were detected with fluorescence quantitative-PCR,which of CCN3 protein in cervical cancer and tumor-adjacent normal tissues of 43 cases were detected with immunohistochemistry.The correlation of the expressions of CCN3 with clinicopathological features was analyzed.ResultsThe CCN3 mRNA expression was higher in cervical cancer than that in tumor-adjacent normal tissues(P<0.05).CCN3 expression rate was 58.14% in cervical cancer,which was higher than 6.98% in normal cervical tissues(P<0.05).High expression of CCN3 was significantly associated with histological grade,tumor size and lymph node metastasis(P<0.05).Conclusion CCN3 expression may play an important role in the occurrence and development of cervical cancer and may be taken as a biomarker in the diagnosis and monitoring of cervical cancer.