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干细胞因子(SCF)是一种新型多功能细胞因子,以可溶型和膜结合型两种形式存在,通过与其酪氨酸激酶受体c-kit结合发挥其生物学作用。SCF及其受体c-kit在肺组织细胞中表达广泛,不仅是肥大细胞重要的活化与趋化因子,而且对嗜酸粒细胞的分化、增殖、活化、趋化过程起重要作用,参与支气管哮喘的气道慢性炎症和气道高反应性过程。深入研究SCF对嗜酸粒细胞的调控作用及机制对哮喘的防治有重要意义。
Stem Cell Factor (SCF) is a novel multifunctional cytokine that exists in both soluble and membrane-bound forms and exerts its biological effects by binding to its tyrosine kinase receptor c-kit. SCF and its receptor c-kit is widely expressed in lung tissue cells, not only is an important activation of mast cells and chemokines, and eosinophil differentiation, proliferation, activation, chemotaxis process plays an important role in bronchial Chronic airway inflammation and airway hyperresponsiveness in asthma. In-depth study of SCF on eosinophil regulatory mechanisms and mechanisms of prevention and treatment of asthma is of great significance.