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目的评价血清胱抑素C在诊断糖尿病肾病中的价值。方法检索多个数据库,对相关文献进行系统评价,用随机效应模型计算纳入研究的总灵敏度、特异度及其它指标,绘制受试者工作特征曲线以探讨本试验的总体诊断特性。结果按照选择标准最终有9项独立研究纳入本次meta分析,合并灵敏度与特异度分别为85%和86%,合并阳性拟然比与阴性拟然比分别为6.23和0.17,合并诊断优势比为54.59,SROC曲线下面积0.9435,SE为0.0273。结论血清胱抑素C水平的检测有助于评估肾小球滤过功能,对糖尿病肾病患者早期肾损害有一定的诊断价值。
Objective To evaluate the value of serum cystatin C in the diagnosis of diabetic nephropathy. Methods A number of databases were searched to systematically evaluate the related literatures. The total sensitivity, specificity and other indicators of the included studies were calculated using the random effects model. The working characteristics of the subjects were plotted to explore the overall diagnostic properties of the trial. Results According to the selection criteria, nine independent studies were finally included in this meta-analysis. The combined sensitivity and specificity were 85% and 86%, respectively. The expected odds ratios for the combined positive and negative odds ratios were 6.23 and 0.17 respectively. The combined diagnostic odds ratio 54.59, area under the SROC curve 0.9435, SE 0.0273. Conclusion The detection of serum cystatin C is helpful to evaluate the glomerular filtration function, and has a certain diagnostic value for early renal damage in patients with diabetic nephropathy.