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目的报告2例复发后呈假肉瘤样变的软骨黏液样纤维瘤病例,探讨其临床病理特征、诊断及鉴别诊断要点。方法对2例复发后呈假肉瘤样变的软骨黏液样纤维瘤进行临床及病理形态分析并文献复习。结果例1,男,13岁,左足第一跖骨肿瘤术后18个月复发;例2,男,9岁,股骨肿瘤术后2年半复发,2例初次术后病理诊断皆为软骨黏液样纤维瘤。复发后术后病理形态包括软骨黏液样纤维瘤结构及假肉瘤样结构。免疫组化显示Vimentin及S-100阳性。结论软骨黏液样纤维瘤为良性肿瘤,复发后异型性明显,呈假肉瘤样形态,诊断应结合临床资料、影像学及整体组织学表现,并与其它恶性肿瘤相鉴别。
Objective To report two cases of pseudomyosarcoid myxoid fibroid fibroma after recurrent, to explore the clinicopathological features, diagnosis and differential diagnosis. Methods Two cases of pseudomyosarcoid myofibroma were resected and reviewed in literature. Results of Example 1, male, 13 years old, left foot first metatarsal tumor recurrence 18 months after surgery; Example 2, male, 9 years old, 2 years and a half after the recurrence of femoral tumor, pathological diagnosis of 2 cases were all initial cartilage mucoid Fibroma. Postoperative pathological changes include cartilage myxoid fibroid structure and pseudosarcoma-like structure. Immunohistochemistry showed Vimentin and S-100 positive. Conclusions Cartilage myxoid fibroma is a benign tumor with obvious atypia after recurrence. It is pseudosarcoma-like morphology. The diagnosis should be based on clinical data, imaging and histological findings, and be differentiated from other malignant tumors.