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增强对流输注(CED)是一项颇具前景的技术,其借助压力驱动流来增强输注药物进入细胞间隙的穿透力。为进一步提升CED的药物分布容积,笔者发明了一种可产生局部亚致死热量的光纤微针装置。本文试图在琼脂糖组织模型中对该技术进行定量表征。在15°C、20°C、25°C和30°C的恒温条件下,染料的输注在质量分数为0.6%的琼脂糖组织模型中进行分析。输注指标通过自定义阴影成像技术和图像处理算法进行定量。利用所获数据构建一个分布容积的经验预测时序模型作为组织模型温度的函数。接下来通过一组概念验证实验来评估液体输注时新型光纤装置产生局部光加热的能力。恒温输注显示温度和分布容积呈正相关,在100 min时,在30°C恒温条件下体积扩散是在15°C恒温条件下的7倍。在光加热(1064 nm,500 mW)过程中,输注呈现相似的效果:与对照组(0 mW)相比,输注体积在4 h时增大了3.5倍。本文的分析和结果为体积扩散的热介导增强提供了特征描述及新思路。
Enhanced Convective Infusion (CED) is a promising technique that uses pressure-driven flow to enhance the penetration of an infusion drug into the intercellular space. In order to further enhance the CED’s drug distribution volume, I invented a fiber microneedle device that can generate local sub-lethal heat. This article attempts to quantify this technique in an agarose tissue model. At constant temperature of 15 ° C, 20 ° C, 25 ° C and 30 ° C, the dye infusions were analyzed in an agarose tissue mass fraction of 0.6%. Infusion indicators are quantified by custom shading techniques and image processing algorithms. Using the data obtained, a volume-based empirical prediction timing model was constructed as a function of tissue model temperature. Next, a set of proof-of-concept experiments were performed to assess the ability of the new fiber optic device to produce localized light heating during liquid infusion. Thermostatic infusion showed a positive correlation between temperature and volume of distribution, with volume diffusion at 30 ° C at 7 ° C at 15 ° C at 100 ° C. Infusion had a similar effect during light heating (1064 nm, 500 mW): Infusion volume increased 3.5-fold at 4 h compared to the control (0 mW). The analysis and results in this paper provide the characterization and new ideas for the thermal-mediated enhancement of volume diffusion.