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目的 探讨妊高征患者体液免疫功能变化。方法 采用常规单相免疫扩散试验测定了正常妊娠 2 48例 ,正常产后 2 8例 ;妊高征治疗前 2 0例 ,治疗后 10 5例 ,产后 2 6例血清IgG、IgA、IgM和C3的浓度。结果 妊高征血清IgG、IgA、IgM和C3 的浓度均比正常妊娠明显降低 (P <0 .0 5 ) ;治疗后妊高征血清IgA、IgM和C3 水平均明显升高 (P <0 .0 5 ) ;产后第 7天妊高征血清IgG、IgA、和C3 恢复至正常妊娠产后水平。结论 妊高征患者体内免疫球蛋白处于低水平 ,其生理性免疫功能受到抑制。
Objective To investigate the changes of humoral immune function in patients with pregnancy induced hypertension. Methods The routine single-phase immunodiffusion test was used to measure the serum levels of IgG, IgA, IgM and C3 in 24 cases of normal pregnancy and 28 cases of normal postpartum pregnancy; 20 cases of PIH before treatment, 105 cases after treatment and 26 cases of postpartum concentration. Results The serum levels of IgG, IgA, IgM and C3 in PIH were significantly lower than those in normal pregnancy (P <0.05). The serum levels of IgA, IgM and C3 were significantly increased after PIH treatment (P <0.05). 0 5). The serum levels of IgG, IgA, and C3 in the PIH after 7 days of delivery were recovered to normal postpartum levels. Conclusion The immunoglobulin in patients with PIH is at a low level and its physiological immune function is inhibited.