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目的探讨在冠心病合并幽门螺杆菌感染患者中肿瘤坏死因子-α诱导蛋白-8样因子-2(TIPE2)的表达水平。方法应用实时荧光定量-聚合酶链式反应检测健康对照组(甲组)、无幽门螺杆菌感染的冠心病组(乙组)和伴幽门螺杆菌感染的冠心病组(丙组)的外周血中TIPE2表达水平。结果无论是否伴幽门螺杆菌感染,冠心病组的TIPE2表达水平均明显低于对照组(P=0.000);伴幽门螺杆菌感染冠心病组的TIPE2表达水平明显低于不伴幽门螺杆菌感染冠心病组的TIPE2表达水平(P=0.000)。结论 TIPE2在冠心病患者的外周血中表达明显降低,且合并幽门螺杆菌感染者明显低于不合并幽门螺杆菌感染者。
Objective To investigate the expression of tumor necrosis factor-α-induced protein-8-like factor-2 (TIPE2) in patients with coronary heart disease complicated with Helicobacter pylori infection. Methods The peripheral blood of healthy control group (group A), non-Helicobacter pylori-infected coronary heart disease group (group B), and Helicobacter pylori-infected coronary heart disease group (group C) were detected by real-time fluorescence quantitative polymerase chain reaction In TIPE2 expression levels. Results The expression of TIPE2 in CHD group was significantly lower than that in control group (P = 0.000), whether with or without Helicobacter pylori infection. The expression of TIPE2 in CHD group with CHD was significantly lower than that without H. pylori infection Heart disease group TIPE2 expression level (P = 0.000). Conclusion The expression of TIPE2 in peripheral blood of patients with coronary heart disease was significantly lower than those without H. pylori infection.