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目的探讨非洛地平对老年高血压患者颈动脉粥样硬化斑块的治疗作用。方法选择老年高血压患者合并颈动脉粥样硬化斑块82例,随机分为非洛地平组(治疗组42例)和盐酸贝那普利组(对照组40例)。用高分辨超声技术检测2组对象的颈动脉内膜中层厚度(IMT)。对2组分别在治疗3个月、9个月及15个月后复查血压和颈动脉IMT。结果2组间血压降低无显著性差异(P>0.05)。但非洛地平组在逆转颈动脉IMT方面优于盐酸贝那普利组(P<0.05)。结论非洛地平除具有良好的降压作用,还具有抗动脉粥样硬化、逆转斑块的作用。
Objective To investigate the therapeutic effect of felodipine on carotid atherosclerotic plaques in elderly patients with hypertension. Methods Eighty-two elderly patients with hypertension and carotid atherosclerosis were selected and randomly divided into felodipine group (42 cases) and benazepril hydrochloride group (40 cases). The carotid artery intima-media thickness (IMT) of two groups was detected by high-resolution ultrasound. Blood pressure and carotid IMT were reviewed in 2 groups after treatment for 3 months, 9 months and 15 months respectively. Results There was no significant difference in blood pressure between the two groups (P> 0.05). However, felodipine group was superior to benazepril hydrochloride group in reversing carotid IMT (P <0.05). Conclusion Felodipine has a good antihypertensive effect, anti-atherosclerosis, reversal of plaque role.