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目的探讨米托蒽醌(M)、阿糖胞苷(A)联合粒细胞集落刺激因子(G-CSF)(MAG方案)治疗老年人急性髓系白血病(AML)的临床疗效。方法采用MAG方案对15例老年人AML患者进行诱导及巩固治疗。结果本组3例1个疗程达完全缓解(CR),6例2个疗程达CR,2例2个疗程达部分缓解(PR),CR率达60.0%,总有效率达73.3%。患者均有不同程度的骨髓抑制,但与常规化疗相比较轻。结论 MAG方案疗效确切,对大多数患者都有较好的耐受性,不良反应轻微,是老年AML的一种安全、有效的治疗方案。
Objective To investigate the clinical efficacy of mitoxantrone (M), cytarabine (A) combined with granulocyte colony-stimulating factor (MAG) in the treatment of acute myeloid leukemia (AML) in the elderly. Methods The MAG program was used to induce and consolidate 15 elderly AML patients. Results In the 3 cases of 1 course of complete remission (CR), 6 cases of 2 courses of CR, 2 cases of 2 courses of partial remission (PR), CR rate of 60.0%, the total effective rate was 73.3%. Patients have varying degrees of myelosuppression, but are less severe than conventional chemotherapy. Conclusion The MAG regimen is effective and has good tolerability to most patients with mild adverse reactions. It is a safe and effective treatment for AML in the elderly.