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目的利用改良氧利用率(MO2UC)指标对心肺复苏期间自主循环恢复早期的氧代谢进行监测研究。方法前瞻性地监测10例心肺复苏病人复苏中的动脉及相关静脉血气,计算MO2UC,并进行动态观察。结果①成活组MO2UC为0.31±0.08,死亡组MO2UC为0.71±0.25,有显著性差异( P<0 001)。②复苏结果比较无任何效果3例死亡,其MO2UC变化呈现出高值或上升趋势(MO2UC=0.82±0.16)。自主循环恢复2 例,最终死亡,其MO2UC呈下降趋势(MO2UC=0.50±0 29)。自主循环、呼吸、意识恢复5例,其MO2UC为0.31±0.08。结论①可用MO2UC-循环状态对心肺复苏进行四分期大循环恢复、微循环障碍或(和)细胞氧利用抑制、细胞氧代谢恢复和偿还组织氧债、恢复正常。②MO2UC曲线的变化还可以作为病人危重程度的预警指标。
OBJECTIVE: To monitor early oxygen metabolism during cardiopulmonary resuscitation (COPD) during cardiopulmonary resuscitation (CPR) by using improved oxygen utilization rate (MO2UC). Methods Prospectively monitor arterial and venous blood gases in resuscitation of 10 patients with cardiopulmonary resuscitation and calculate MO2UC and observe dynamically. Results ① The survival rate of MO2UC was 0.31 ± 0.08, and the death rate of MO2UC was 0.71 ± 0.25 (P <0.001). ② There was no any effect in the resuscitation. There were 3 deaths and the MO2UC showed a high or increasing trend (MO2UC = 0.82 ± 0.16). Two cases recovered spontaneously and eventually died. The MO2UC showed a decreasing trend (MO2UC = 0.50 ± 0.29). 5 cases of spontaneous circulation, respiration, consciousness recovery, the MO2UC was 0.31 ± 0.08. Conclusions ① MO2UC-cycle state can resume CPR in four phases, inhibit microcirculation or (and) cell oxygen utilization, restore cellular oxygen metabolism and repay tissue oxygen debt, and return to normal. ②MO2UC curve changes can also be used as an indicator of the severity of the patient.