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目的:观察白芍总苷(TGP)联合来氟米特(LEF)治疗活动期类风湿关节炎(RA)的临床疗效。方法:将79例活动期RA患者随机分为两组,治疗组39例服用TGP和LEF,对照组40例单用LEF,疗程均为24周,采用美国风湿病学会(ACR)推荐的RA疾病活动评价核心指标对两组治疗前后进行评估。结果:治疗后两组病情活动主要指标评分均有显著降低,治疗前后比较差异均有非常显著性意义(P<0.01),治疗组评分降低优于对照组,差异有显著性意义(P<0.05)。治疗组达到ACR20、ACR50、ACR90疗效标准的分别为30.77%、25.64%、41.03%,总有效率97.44%;对照组达到ACR20、ACR50、ACR90疗效标准的分别为20%、32.5%、27.5%,总有效率85%。结论:TGP联合LEF治疗活动期RA的疗效明显优于单用LEF的疗效,且具有较好的安全性。
Objective: To observe the clinical efficacy of TGP combined with leflunomide (LEF) in the treatment of active rheumatoid arthritis (RA). Methods: A total of 79 patients with active RA were randomly divided into two groups. TGP and LEF were given to 39 patients in the treatment group and 40 patients in the control group were treated with LEF alone for 24 weeks. RA patients were treated with the American College of Rheumatology (ACR) Activity evaluation of the core indicators of the two groups before and after treatment assessment. Results: After treatment, the scores of major indexes of disease activity in both groups were significantly decreased, with significant difference before and after treatment (P <0.01), and the score of treatment group was lower than that of control group (P <0.05 ). The curative effect of ACR20, ACR50 and ACR90 in treatment group were 30.77%, 25.64% and 41.03% respectively, and the total effective rate was 97.44%. The therapeutic effect of ACR20, ACR50 and ACR90 in control group was 20%, 32.5% and 27.5% The total efficiency of 85%. Conclusion: TGP combined with LEF treatment of active RA was significantly better than the efficacy of LEF alone, and has good safety.