氯林可霉素为林可霉素的7—氯—7去氧衍生物。前者的优点为:在胃肠道吸收较好且不受食物影响,对同种细菌的最小抑菌浓度较低且其抗菌谱包括多种厌氧菌和某些原虫。但自1973年发现氯林可霉素可引起假膜性结肠炎,至1975年1月已有340例报告,其中85例死亡,内20例假膜性结肠炎是致死的主要因素。 Clindamycin is lincomycin 7-chloro-7 deoxy derivative. The former has the following advantages: better absorption in the gastrointestinal tract and food-free effects, lower minimum inhibitory concentration (MIC) on the same bacteria and its antibacterial spectrum including various anaerobic bacteria and some protozoa. However, clindamycin was found to have caused pseudomembranous colitis since 1973. As of January 1975, 340 cases were reported, of which 85 were fatal. Twenty cases of pseudomembranous colitis were the major causes of death.