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目的:探讨超声筛查11~14周胎儿颈项透明层厚度(NTT)增厚与胎儿心脏畸形的关系。方法:选取2013年8月至2015年7月博罗县妇幼保健院产前检查检出11~14周NTT增厚69例,根据NTT厚度分为三组,2.5~3.5 mm列为A组23例,3.6~4.5 mm列为B组22例,>4.5 mm列为C组24例。检查测出NTT≥3.6 mm病例建议于孕16~20周行羊水刺穿对细胞染色体的核型进行检查;对于NTT≥2.5 mm病例,建议于孕18~24周行中期超声检查。所有病例均随访至分娩后3月,观察妊娠结局,并保留脐带血,拟必要时行染色体核型检验。结果:心脏畸形在A组、B组、C组中依次上升,差异具有统计学意义(P<0.05)。结论:随着NTT厚度的增加,胎儿心脏畸形的几率也增加。
Objective: To investigate the relationship between fetus heart deformity and fetal thickened NTT thickness at 11 ~ 14 weeks after ultrasound screening. Methods: From August 2013 to July 2015, 69 cases of NTT thickening were detected in prenatal examination at Boluo Maternal and Child Health Hospital from 11 to 14 weeks, divided into three groups according to the thickness of NTT and 2.5 to 3.5 mm as group A For example, 3.6-4.5 mm were classified as group B in 22 cases and> 4.5 mm in group C as 24 cases. Check the measured NTT â ‰ ¥ 3.6 mm cases suggest that 16 to 20 weeks of pregnancy amniotic fluid piercing the cell chromosome karyotype examination; for NTT â ‰ 2.5 mm cases, it is recommended at 18 to 24 weeks of pregnancy underwent mid-term ultrasound. All cases were followed up to March after delivery, observe the pregnancy outcome, and retain cord blood, if necessary, the line of karyotype examination. Results: Cardiac malformations increased in groups A, B and C, with statistical significance (P <0.05). Conclusion: With the increase of NTT thickness, the probability of fetal heart malformations also increased.