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m-AMSA(4′[9-吖啶基氨基]甲基砜-间-茴香氨,4′-[9-acridinylamino] methanesulphon-m-anisi-dide是1974年由新西兰Cain等合成的吖啶衍生物,它能嵌入DNA内,对包括L 1210白血病在内的多种动物肿瘤有细胞毒作用。本文简述本品在急性白血病第Ⅰ、Ⅱ期及原发性肝癌和头颈部肿瘤第Ⅱ期的临床研究结果。在急性白血病第Ⅰ、Ⅱ期临床研究中,选择白血病患者32例,其中18例成人是用阿霉素、阿糖胞苷和6-硫鸟嘌呤组成的联合化疗无效或复发的急性粒细胞性
m-AMSA (4’[9-acridinylamino]methylsulfone-m-anisidine, 4’-[9-acridinylamino] methanesulphon-m-anisi-dide) was derived from acridine synthesized in 1974 by New Zealand Cain et al. It can be embedded in DNA and has a cytotoxic effect on a variety of animal tumors including L 1210. This article briefly describes this product in Phase I and II of acute leukemia and primary liver cancer and head and neck cancer. Phase II Clinical Results: In the Phase I and II clinical studies of acute leukemia, 32 patients with leukemia were selected, and 18 adults were treated with doxorubicin, cytarabine, and 6-thioguanine. Recurrent acute granulocytic