通过分子克隆技术将ＩＬ６基因导入大肠癌细胞ＨＴ２９，建立了目的基因转导株ＨＴ２９ＩＬ６细胞。该转导株接种于裸鼠皮下后，与非转导株相比，长出肿瘤的时间延后，最终瘤径明显较小，而且移植瘤标本镜下可见大量的核固缩、核染色质加深、核断裂等凋亡细胞。用携带ＩＬ６基因的重组逆转录病毒液感染大肠癌细胞Ｌｏｖｏ后，仅以１．２５μｍｏｌ／Ｌ的ＶＵＭＯＮ２６（简称ＶＭ２６）即可诱导该转染株发生明显凋亡，而非转染株用５μｍｏｌ／Ｌ浓度的ＶＭ２６方能奏效。可见，转导株对细胞凋亡诱导剂的敏感性明显增强。提示ＩＬ６基因表达可促进或诱导肿瘤细胞进入凋亡过程，从而抑制肿瘤的形成与发展。 Through molecular cloning technology will IL  6 gene into colorectal cancer cells HT  29, the purpose of the gene transfer vector HT29 IL  6 cells. After inoculation of the transductant into the skin of nude mice, compared with the non-transduced strain, the growth time of the tumor was delayed and the final tumor diameter was significantly smaller. In addition, a large number of nuclear pyknosis and nuclear chromatin Deepen, nuclear rupture and other apoptotic cells. With recombinant retrovirus carrying IL6 gene infection of colorectal cancer cells Lovo, only 1.25μmol / L of VUMON26 (referred to as VM  26) can induce significant apoptosis of the transfected strains, rather than Transfection with 5μmol / L concentration of VM  26 party can work. It can be seen that the sensitivity of the transduction strain to the apoptosis inducer is obviously enhanced. Prompt IL  6 gene expression can promote or induce tumor cells into the apoptosis process, thereby inhibiting the formation and development of cancer.