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1955年 Cronkhite 与 Canada 二人报告2例伴随皮肤色素沉着、脱毛、指(趾)甲萎缩,无遗传因素的广泛消化道息肉病人.1966年 Jarnum 将其命名为 Cronkite-Canada 综合征(多发性消化道息肉综合征,下简称本征).到1982年全世界报告有113例,其中日本报告78例.现将本征的病因.发病机理、临床表现、治疗及预后综述如下.一、病因与发病机理本征的病因与发病机理至今尚未阐明.多数学者认为由外因致病的病例多,推断是某些感染或药物的特异性反应.本征最初有味觉异常、口渴、食欲不振等.有人认为味觉异常是微量元素锌和铜吸收障碍或某些药物影响的结果.本征早期用蛋白同化激素、肾上腺皮质激素、抗胞浆素治疗2年以上有显效的病例,很少再发,并能长期生存,还有的病例只用对症治疗甚至不治自愈.因此认为本征是由某种外因、免疫不全或变态反应所致.
In 1955, Cronkhite and Canada reported two cases of extensive gastrointestinal polyps associated with pigmentation, hair loss, nail atrophy and no genetic factors. In 1966 Jarnum named it Cronkite-Canada syndrome (multiple digestive Polyps syndrome, hereinafter referred to as the intrinsic.) By 1982 the world reported 113 cases, of which 78 were reported in Japan now etiological etiology, pathogenesis, clinical manifestations, treatment and prognosis are summarized as follows. The etiology and pathogenesis of the pathogenesis of etiology has not been elucidated yet.Most scholars believe that there are many cases of extraneous pathogenicity, which are inferred to be specific reactions of some infections or drugs.Identity initially has abnormal taste, thirst, loss of appetite and so on. Some people think that the abnormal taste is the result of the imbalance of trace elements zinc and copper absorption or the influence of certain drugs.Intravenous early use of protein anabolic hormones, adrenal cortex hormones, anti-plasmatic treatment of more than 2 years of effective cases, rarely recurrence, And long-term survival, and some cases only symptomatic treatment or even self-healing, so that the intrinsic is caused by some external, immune insufficiency or allergic reaction.