论文部分内容阅读
目的:探讨抑酸药H2受体拮抗剂与质子泵抑制剂对急性上消化道出血的即刻疗效.方法:212例急性上消化道出血住院患者随机分成四组.治疗组分别静脉应用奥美拉唑40mg,潘托拉唑40mg及西咪替丁800mg,对照组不用药物,胃镜检查观察、评价止血效果.结果:止血有效率奥美拉唑组为93.5%,潘托拉唑组为86.8%,西咪替丁组为68.2%,与对照组(31.6%)比较,抑酸药止血效果明显(P<0.01).奥美拉唑组与潘托拉唑相比疗效相似,止血有效率分别为93.5%和86.8%(P>0.05).明显优于H2受体拮抗剂西咪替丁(P<0.05).结论:质子泵抑制剂静脉应用治疗急性上消化道出血疗效优于H2受体拮抗剂.
Objective: To investigate the immediate curative effect of antacids H2 receptor antagonists and proton pump inhibitors on acute upper gastrointestinal bleeding.Methods: 212 patients with acute upper gastrointestinal bleeding were randomly divided into four groups.The treatment groups were given omeprazole 40 mg of prazosin, 40 mg of pantoprazole and 800 mg of cimetidine.Results: The hemostatic effective rate was 93.5% in the omeprazole group and 86.8% in the pantoprazole group, , And 68.2% in the cimetidine group, compared with 31.6% in the control group (P <0.01). The curative effect of omeprazole group was similar to that of the pantoprazole group, and the effective rates of hemostasis (93.5%) and 86.8% (P> 0.05), respectively, which was significantly better than that of H2 receptor antagonist cimetidine (P <0.05) .Conclusion: The effect of proton pump inhibitor intravenous injection on acute upper gastrointestinal bleeding is better than H2 receptor Antagonists.