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[目的]对丙硫菌唑的合成路线进行优化,优化后的制备工艺更加简便、高效。[方法]以1-氯环丙基甲酸乙酯、邻氯苯乙酸乙酯和1-硫-3-氮杂环丁烷并[2,3,e]-1,2,4-三氮唑为原料,经过2步反应合成丙硫菌唑,优化条件下总收率达76.8%。[结果]目标化合物经~1H NMR光谱进行确认。[结论]该方法操作简单、反应条件温和、丙硫菌唑的收率高,适合工业化生产。
[Objective] The synthetic route of prothioconazole was optimized, and the optimized preparation process was more simple and efficient. [Method] With 1-chlorocyclopropanecarboxylic acid ethyl ester, o-chlorophenylacetic acid ethyl ester and 1-thio-3-azetidino [2,3] e] -1,2,4-triazole As raw materials, prothioconazole was synthesized in two steps. Under the optimal conditions, the total yield was 76.8%. [Result] The target compound was confirmed by ~ 1H NMR spectroscopy. [Conclusion] The method was simple and the reaction conditions were mild. The yield of prothioconazole was high, which was suitable for industrial production.