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他汀类药物是最为经典和有效的降脂药物,此类药物通过竞争性抑制内源性胆固醇合成限速酶羟甲基戊二酰辅酶A(HMG-CoA)还原酶,阻断细胞内甲羟戊酸代谢途径,使细胞内胆固醇合成减少,从而反馈性刺激细胞膜表面(主要为肝细胞)低密度脂蛋白(LDL)受体数量和活性增加,使血清胆固醇清除增加,水平降低。研究证实他汀类药物还具有不依赖于降脂的多效性作用,主要有抗细胞增殖、抗氧化清除自由基、抗炎
Statins are the most classic and effective lipid-lowering drugs that block the intracellular methylethylhydroxygen by competitively inhibiting the enzyme HMG-CoA reductase, the rate-limiting enzyme in endogenous cholesterol synthesis Valerate metabolic pathway to reduce the synthesis of intracellular cholesterol, thereby feedback stimulation of cell membrane surface (mainly liver cells) low density lipoprotein (LDL) receptor number and activity increased, so that serum cholesterol clearance increased, the level decreased. Studies have shown that statins also have a pleiotropic effect independent of lipid-lowering, mainly anti-cell proliferation, antioxidant free radical scavenging, anti-inflammatory